Sun, Zhongyu; Fan, Jiajin; Wang, Jiayue; Wang, Fei; Nie, Lei; Li, Lian; Dong, Qin; Li, Can; Du, Ranran; Quan, Shuang; Zang, Hengchang published the article 《Assessment of the human albumin in acid precipitation process using NIRS and multi-variable selection methods combined with SPA》. Keywords: human albumin acid precipitation NIRS projection algorithm.They researched the compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide( cas:76-60-8 ).Product Details of 76-60-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:76-60-8) here.
Human albumin (HA) content was determined by near IR spectroscopy (NIRS), which was an process anal. technol. (PAT) tool, to realize process monitoring during acid precipitation Eight batches of acid precipitation process samples were simulated in laboratory, and HA contents were determined by bromocresol green (BCG) method. Five batches were selected as calibration set and three batches were selected as validation set to build partial least squares regression (PLSR) model of HA content. Before the establishment of PLSR model, partial samples and different variable selection methods were compared in details and 35 variables were finally selected. The successive projection algorithm (SPA) combined with the multi-variable selection methods (CC, UVE, CARS, SCARS, FiPLS, MWPLS, BiPLS) could obtain more useful information than the single method. The RMSECV and RMSEP values of the optimal PLSR model were 0.7038 g/L and 0.5893 g/L, resp. Meanwhile, NIRS was an effective tool and could be successfully used for quant. monitoring during acid precipitation process. To some extent, it could provide theor. supports for quality control with a fast, nondestructive and low-cost NIRS in monitoring the complex biol. production process.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles