Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 29046-78-4, is researched, Molecular C4H10Cl2NiO2, about Scalability of Visible-Light-Induced Nickel Negishi Reactions: A Combination of Flow Photochemistry, Use of Solid Reagents, and In-Line NMR Monitoring, the main research direction is arylmethane preparation; nickel catalyst photochem Negishi coupling benzylic bromide flow reaction; benzylzinc bromide formation observation inline NMR photochem Negishi coupling.Product Details of 29046-78-4.
Photochem. Negishi coupling reactions of benzylic bromides and an aryl bromide and iodide in the presence of NiCl2(glyme) and 4,4′-di-tert-butyl-2,2′-bipyridine using solid activated zinc as reductant were performed on multigram scale using a flow reactor; the benzylzinc bromide intermediates were generated using a column containing the solid activated zinc and their formation was monitored in line using a benchtop NMR spectrometer. Adjusting reaction times and concentrations was critical in maximizing product yield, while the changing the reactor type allowed a significant increase in scale.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles