Reference of Nickel(II) chloride ethylene glycol dimethyl ether complex. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Development and Execution of a Ni(II)-Catalyzed Reductive Cross Coupling of Substituted 2-Chloropyridine and Ethyl 3-Chloropropanoate. Author is Nimmagadda, Sri Krishna; Korapati, Satish; Dasgupta, Debottam; Malik, Noormohamed Abdul; Vinodini, Arun; Gangu, Aravind S.; Kalidindi, Srinivas; Maity, Prantik; Bondigela, Siva Sankar; Venu, Alla; Gallagher, William P.; Aytar, Selin; Gonzalez-Bobes, Francisco; Vaidyanathan, Rajappa.
The development and scale up of a nickel-catalyzed reductive cross-electrophile coupling reaction between a substituted 2-chloropyridine and Et 3-chloropropanoate using manganese dust as the terminal reductant is reported. Several additives were screened for the activation of the manganese reductant in situ, and TESCl was found to provide the optimal conversion. A Focused Beam Reflectance Measurement (FBRM) probe was utilized to monitor particle attrition as well as manganese activation during the reaction. Modeling was employed to garner an understanding of mixing requirements that would ensure effective suspension of the manganese during scale-up. The process was successfully demonstrated on a 7 kg scale and afforded >60% yield of compound I.
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