Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Enantioselective conversion of aldehydes to cyanohydrins by a catalytic system with separate chiral binding sites for aldehyde and cyanide components.Electric Literature of C19H18N2O2.
A new enantioselective method for the synthesis of chiral cyanohydrins from aldehydes and trimethylsilyl cyanide is described which uses a pair of synergistic chiral reagents, one to activate the aldehyde and the other to provide an equivalent of chiral cyanide ion. Thus, cyclohexanecarboxaldehyde was treated with Me3SiCN in the presence of chiral bisoxazoline I and the Mg complex II in EtCN-CH2Cl2 to give 94% the (S)-cyanohydrin silyl ether III in 94% ee.
Although many compounds look similar to this compound(132098-59-0)Electric Literature of C19H18N2O2, numerous studies have shown that this compound(SMILES:C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles