The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Phenylpyridine(SMILESS: C1(C2=CC=CC=C2)=NC=CC=C1,cas:1008-89-5) is researched.Computed Properties of C4H10Cl2NiO2. The article 《Inhibition of (dppf)nickel-catalysed Suzuki-Miyaura cross-coupling reactions by α-halo-N-heterocycles》 in relation to this compound, is published in Chemical Science. Let’s take a look at the latest research on this compound (cas:1008-89-5).
A nickel/dppf catalyst system was found to successfully achieve the Suzuki-Miyaura cross-coupling reactions of 3- and 4-chloropyridine and of 6-chloroquinoline but not of 2-chloropyridine or of other α-halo-N-heterocycles. Further investigations revealed that chloropyridines underwent rapid oxidative addition to [Ni(COD)(dppf)] but that α-halo-N-heterocycles led to the formation of stable dimeric nickel species that were catalytically inactive in Suzuki-Miyaura cross-coupling reactions. However, the corresponding Kumada-Tamao-Corriu reactions all proceed readily, which was attributed to more rapid transmetalation of Grignard reagents.
After consulting a lot of data, we found that this compound(1008-89-5)Reference of 2-Phenylpyridine can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles