Lopez-Valdez, German;Olguin-Uribe, Simon;Miranda, Luis D. published 《Carbamoyl radicals from carbamoylxanthates: a facile entry into isoindolin-1-ones》 in 2007. The article was appeared in 《Tetrahedron Letters》. They have made some progress in their research.Formula: C9H9NO2 The article mentions the following:
It has been found that carbamoylxanthates (e.g., BnN(CMe3)C(O)S2COEt) derived from secondary t-Bu amines are stable compounds which function as efficient sources of carbamoyl radicals. The carbamoylxanthates derived from t-butylbenzylamines can be efficiently transformed into 2-t-butylisoindolin-1-ones (e.g. I) via an oxidative radical cyclization process. The carbamoylxanthates derived from N-t-butylamino olefins underwent the expected cyclization/xanthate-transfer process to afford the corresponding pyrrolidones and piperidones under thermally induced DLP fragmentation conditions and in the presence of catalytic Et3B in air, at room temperature The experimental procedure involved many compounds, such as 6-Methoxyisoindolin-1-one (cas: 132680-54-7) .
6-Methoxyisoindolin-1-one(cas:132680-54-7 Formula: C9H9NO2) also interacts with inhibitors of other topoisomerases such as camptothecin and etoposide. It has been shown that combining these two drugs can inhibit cancer cells more effectively than either drug alone.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles