Previous studies have identified that indole-oxidases are present in P. putida, whose major ligands are heterocyclic substrates and have an interesting affinity when the substrate is indole. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. These enzymes oxidize the ring so the substrate turns into Indigo. Application In Synthesis of 19005-93-7.
Hang, Qing-Qing;Liu, Si-Jia;Yu, Lei;Sun, Ting-Ting;Zhang, Yu-Chen;Mei, Guang-Jian;Shi, Feng research published 《 Design and Application of Indole-Based Allylic Donors for Pd-Catalyzed Decarboxylative Allylation Reactions》, the research content is summarized as follows. In addition, the first application of these indole-based allylic donors I (R = H, Me) in palladium-catalyzed decarboxylative [3+2] cycloaddition and allylic amination has been achieved by reacting with isocyanates R1N=C=O (R1 = 4-fluorophenyl, cyclopentyl, 3-chloropropyl, etc.) and N-Boc-benzenesulfonyl amines N-Boc-R2C6H4SO2NR3 (R2 = H, 2-F, 3-Br, 4-Me, etc.; R3 = H), resp. This approach represents the first design of indole-based allylic donors I, which is helpful for settling the challenge of designing and developing a new class of heterocycle-based allylic donors II, N-Boc-R2C6H4SO2NR3 (R3 = (E)-3-(1H-indol-2-yl)-prop-2-en-1-yl, (E)-3-(5-methyl-1H-indol-2-yl)-prop-2-en-1-yl) for Pd-catalyzed decarboxylative allylation reactions. Moreover, the application of this new class of allylic donors in cycloadditions and substitutions will add new contents to the research field of decarboxylative allylation.
19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., Application In Synthesis of 19005-93-7
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles