Previous studies have identified that indole-oxidases are present in P. putida, whose major ligands are heterocyclic substrates and have an interesting affinity when the substrate is indole. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. These enzymes oxidize the ring so the substrate turns into Indigo. Reference of 19005-93-7.
Sehout, Imene;Boulebd, Houssem;Boulcina, Raouf;Nemouchi, Sara;Bendjeddou, Lamia;Bramki, Amina;Merazig, Hocine;Debache, Abdelmadjid research published 《 Synthesis, crystal structure, Hirshfeld surface analysis, biological evaluation, DFT calculations, and in silico ADME analysis of 4-arylidene pyrazolone derivatives as promising antibacterial agents》, the research content is summarized as follows. The present paper describes an ultrasound-assisted synthesis of a series of 4-arylidene-1H-pyrazol-5(4H)-one derivatives, I [R = 4-HOC6H4, thiophen-2-yl, 4-MeOC6H4, etc.], catalyzed by sulfamic acid. The prepared compounds were characterized by phys. and spectroscopic techniques, and for compound I [R = 3,5-(MeO)2C6H3] by single crystal X-ray diffraction anal. Theor. calculations, such as mol. structure optimization, frontier MOs, mol. electrostatic potential, and mol. descriptors, have been performed in order to get insight into the mol. structure and chem. reactivity of the synthesized compounds The antibacterial activity of all compounds was assessed against six bacterial strains; and it was found that these compounds are good inhibitors of Gram-pos. bacteria rather than Gram-neg. In addition, good oral bioavailability was predicted for all compounds by in silico calculations of ADME (absorption, distribution, metabolism, and elimination) and pharmacokinetic parameters.
19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., Reference of 19005-93-7
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles