Gopalaiah, Kovuru; Tiwari, Ankit published the artcile< Synthesis of (E)-3-Alkylideneindolin-2-ones by an Iron-Catalyzed Aerobic Oxidative Condensation of Csp3-H Bonds of Oxindoles and Benzylamines>, Safety of 4-Chloroindolin-2-one, the main research area is alkylideneindolinone preparation iron catalyst oxidative condensation oxindole benzylamine.
A novel synthetic route for the construction of (E)-3-alkylideneindolin-2-ones through iron-catalyzed aerobic oxidative condensation of oxindoles with benzylamines was developed. This oxidative reaction involves a sequence of C-H activation, amine self-condensation, nucleophilic addition, and C-C double bond formation. The synthetic importance of this protocol was demonstrated by preparing tyrosine kinase inhibitors, anticonvulsant and antitumor agents, and other valuable 3-alkylideneindolin-2-one derivatives Key intermediates were isolated and a plausible mechanistic pathway for the reaction is discussed.
European Journal of Organic Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 20870-77-3 belongs to class indole-building-block, and the molecular formula is C8H6ClNO, Safety of 4-Chloroindolin-2-one.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles