Sako, Kumiko’s team published research in Bioorganic & Medicinal Chemistry in 2008-04-01 | 4771-48-6

Bioorganic & Medicinal Chemistry published new progress about Antiviral agents. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, COA of Formula: C10H9NO.

Sako, Kumiko; Aoyama, Hiroshi; Sato, Shinichi; Hashimoto, Yuichi; Baba, Masanori published the artcile< γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity>, COA of Formula: C10H9NO, the main research area is bovine viral diarrhea virus carboline derivative preparation SAR.

Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. BVDV is thought to be a good model for human hepatitis C virus. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC50 of 0.26 μM.

Bioorganic & Medicinal Chemistry published new progress about Antiviral agents. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, COA of Formula: C10H9NO.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles