EL-Gammal, Ohyla A.; Alshater, Heba; El-Boraey, Hanaa A. published the artcile< Schiff base metal complexes of 4-methyl-1H-indol-3-carbaldehyde derivative as a series of potential antioxidants and antimicrobial: Synthesis, spectroscopic characterization and 3D molecular modeling>, HPLC of Formula: 4771-48-6, the main research area is transition metal indolylmethylenenicotinohydrazide complex preparation antioxidant antibacterial antifungal DFT.
Novel mononuclear Fe(III), Cu(II), Cd(II), Sn(IV) and binuclear Ni(II) and Hg(II) complexes with the Schiff base ligand: (E)-N’-((4-methyl-1H-indol-3-yl)methylene) nicotinohydrazide were synthesized. The elucidation of the structure of the prepared compounds were performed by elemental analyses, magnetic measurements, TG, 3-dimensional mol. modeling, molar conductance techniques and by various spectroscopic (IR, 1H NMR, UV-Visible, EPR) tools. Antioxidant activity in vitro by DPPH scanning of the ligand and its metal complexes was studied. All test compounds are excellent antioxidants and better than the standard (Ascorbic acid).[Sn(HL)Cl2(OH)2]·2H2O complex (5) showed the highest antioxidant activity. Also, the ligand and its metal complexes were screened against the sensitive organisms Staphylococcus aureus as Gram-pos. bacteria, Escherichia coli as Gram-neg. bacteria and two strains of fungi (Aspergillus flavus and Candida albicans). All metal complexes have higher antimicrobial activity than the metal free ligand and the binuclear [Hg2(HL)Cl4]·EtOH complex (6) possessed excellent antibacterial activity better than the standard drug Ampicillin (antibacterial agent) and showed excellent antifungal activity against Aspergillus flavus, better than Amphotericin B (antifungal agent).
Journal of Molecular Structure published new progress about Antibacterial agents. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, HPLC of Formula: 4771-48-6.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles