《Water-DMSO-promoted one-pot synthesis of two new series of dihydropyrrolo[2,3-h]quinolines》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Liao, Hui; Zhu, Qiuhua. HPLC of Formula: 885518-25-2 The article mentions the following:
Here, two new series of dihydropyrrolo[2,3-h]quinolines I (R1 = Me, Et, t-Bu; R2 = H, F, Cl; R3 = H, Me; R4 = C6H5, 4-FC6H4, 4-MeC6H4, etc.) with more substituents on the quinoline ring were efficiently synthesized via catalyst-free three-component reaction (3CR) of but-2-ynedioates, 4-aminoindoles and aldehydes or isatins in a DMSO-water (volume ratio: 2.5 : 1) mixture in moderate to good yields. A possible mechanism was proposed based on the crucial and promoted effects of water and DMSO in the 3CR, resp. In addition, it was found that dihydropyrrolo[2,3-h]quinolines could be quant. oxidized into new pyrrolo[2,3-h]quinolines at room temperature using Cu(NO3)2 as an oxidant. This work affords efficient synthesis methods for constructing a library of new pyrrolo[2,3-h]quinolines and is expected to promote the research on the bioactivities of pyrrolo[2,3-h]quinolines. In the part of experimental materials, we found many familiar compounds, such as 6-Fluoro-1H-indol-4-amine(cas: 885518-25-2HPLC of Formula: 885518-25-2)
6-Fluoro-1H-indol-4-amine(cas: 885518-25-2) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 885518-25-2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles