Wan, Xiao; Sun, Meng; Wang, Jing-Yi; Yu, Lei; Wu, Qiong; Zhang, Yu-Chen; Shi, Feng published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Regio- and enantioselective ring-opening reaction of vinylcyclopropanes with indoles under cooperative catalysis》.SDS of cas: 399-52-0 The article contains the following contents:
The title reaction has been established under the cooperative bimetallic catalysis of iridium and copper catalysts, which afforded indole C3-allylation products I [R = CH(CN)2, CH(C(O)2Et)2; R1 = 2-Me, 5-Br, 7-F, etc.; R2 = H, Me] with branched selectivity in moderate yields (up to 78%) and good enantioselectivities (up to 97 : 3 er). This reaction not only represents the first catalytic asym. ring-opening reaction of vinylcyclopropanes like 1,1-dicyano-2-vinylcyclopropane and 1,1-di-Et 2-ethenyl-1,1-cyclopropanedicarboxylate with C3-unsubstituted indoles II, but also has provided an atom-economic and straightforward method for the synthesis of C3-allylic indoles I with high regio- and enantioselectivity. In addition to this study using 5-Fluoro-1H-indole, there are many other studies that have used 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0) was used in this study.
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.SDS of cas: 399-52-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles