On December 25, 2000, Pasquier, Corinne; Naili, Said; Mortreux, Andre; Agbossou, Francine; Pelinski, Lydie; Brocard, Jacques; Eilers, Juergen; Reiners, Iris; Peper, Viola; Martens, Juergen published an article.Recommanded Product: 79815-20-6 The title of the article was Free and Cr(CO)3-Complexed Aminophosphine Phosphinite Ligands for Highly Enantioselective Hydrogenation of α-Functionalized Ketones. And the article contained the following:
The synthesis and characterization of a new series of aryl- and cycloalkyl-substituted aminophosphine phosphinites, e.g. I (R = cyclopentyl), obtained from the reaction of the three precursors (S)-2-hydroxymethylazetidine, (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline, and (S)-2-hydroxymethylindoline and chlorophosphines is described. The aromatic ring in (S)-2-hydroxymethylindoline has allowed the synthesis and isolation of tricarbonyl chromium complexed amino alcs., which were similarly converted into the corresponding aminophosphine phosphinites, presenting a stereogenic center and a planar chirality. Ligand I ((S)-Cp,Cp-IndoNOP) revealed an unprecedented 31P NMR fluxional behavior related to a rotation inhibition around the P-heteroatom (N and O) bonds. These new AMPP ligands were used in the enantioselective hydrogenation of various α-functionalized ketones, i.e., dihydro-4,4-dimethyl-2,3-furandione 14, N-benzyl benzoylformamide 15, Et pyruvate 16, and 2-(N,N-dimethyl)aminoacetophenone hydrochloride 17. The stereoelectronic effects generated by the presence of the tricarbonyl chromium moiety onto the hydrogenations have been assessed. The beneficial effect of the matching chiralities in ligand associated with the use of the most appropriate nonchiral ligand Cl has resulted in a win of 13% of ee for the rhodium-based hydrogenation of 15. While using the most suitable new chiral AMPP ligand from this study, the four above-mentioned substrates were converted into the corresponding optically active alcs. in >99% ee (14/I), >99% ee (15/I), 87% ee (16/I), and >99% ee (17/I), resp. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: 79815-20-6
The Article related to chromium complexed aminophosphine phosphinite ligand preparation catalyst enantioselective hydrogenation, functionalized ketone enantioselective hydrogenation catalyst chromium complexed aminophosphine phosphinite, rhodium ruthenium aminophosphine phosphinite complex catalyst enantioselective hydrogenation ketone and other aspects.Recommanded Product: 79815-20-6
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles