On April 17, 2002, Peglion, Jean-Louis; Vilaine, Jean-Paul; Villeneuve, Nicole; Thollon, Catherine; Bourguignon, Marie-Pierre; Poitevin, Christophe published a patent.Application In Synthesis of 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Preparation of heterocyclic moiety-containing cyclobutenedione derivatives for use in the treatment of atherosclerosis. And the patent contained the following:
The title compounds are prepared [e.g., 3-(2,3-dihydro-1H-indol-1-yl)-4-[2-[4-(phenoxymethyl)-1-piperidinyl]ethylamino]-3-cyclobutene-1,2-dione methanesulfonate; m.p. 209-213°], along with a pharmaceutical dosage form containing them, and are useful in the treatment of diseases pertaining to endothelial dysfunction (e.g., atherosclerosis). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Application In Synthesis of 6-Chloro-2,3-dihydro-1H-indole
The Article related to dihydroindolylphenoxymethylpiperidinylethylaminocyclobutenedione methanesulfonate preparation antiatherosclerotic, cyclobutenedione derivative preparation antiatherosclerotic and other aspects.Application In Synthesis of 6-Chloro-2,3-dihydro-1H-indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles