He, Yi; Wu, Danjun; Li, Zhenghua; Robeyns, Koen; Van Meervelt, Luc; Van der Eycken, Erik V. published an article in 2019, the title of the article was Facile construction of diverse polyheterocyclic scaffolds via gold-catalysed dearomative spirocyclization/1,6-addition cascade.Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde And the article contains the following content:
A gold-catalyzed post-Ugi chemo- and diastereoselective cascade dearomative spirocyclization/1,6-addition sequence was disclosed for the synthesis of diverse fused polyheterocyclic scaffolds such as I [R1 = H, Me, Ac, Bn; R2 = H, Me; R3 = n-Bu, t-Bu, cyclohexyl, Bn etc.; R4 = H, Me, n-Pr, n-Bu, Ph; R5 = H, Me] bearing indole, pyrrole, benzothiophene, furan or electron-rich arene moieties from easily available building blocks. The effectiveness and efficiency of this diversity-oriented approach had proved in the rapid construction of 28 fused polyheterocyclic scaffolds with a good building-block variability and structural complexity in two operational steps. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde
The Article related to fused polyheterocycle chemoselective diastereoselective preparation, adduct ugi tandem dearomative spirocyclization addition gold catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles