Das, Krishna Kanta; Ghosh, Asim Kumar; Hajra, Alakananda published an article in 2022, the title of the article was Late-stage ortho-C-H alkenylation of 2-arylindazoles in aqueous medium by Manganese(I)-catalysis.Synthetic Route of 79815-20-6 And the article contains the following content:
Earth-abundant and water-tolerant manganese(I) catalyzed alkenylation of 2-arylindazoles I (R = H, F, Cl; R1 = H, 4-Me, 3-Cl, etc.) with alkyl and aryl alkynes R2CCR3 (R2 = H, Ph, Me; R3 = hexyl, Ph, thiophen-3-yl, etc.) through C-H bond activation is described with a unique level of E-selectivity. The reaction proceeds through the control of C3 nucleophilicity of 2-aryl indazoles. This method is applied to the late-stage functionalization of complex mols. including ethinylestradiol, norethisterone, and N-protected amino acid derivatives, e.g., prop-2-yn-1-yl (tert-butoxycarbonyl)-L-phenylalaninate. The kinetic isotope studies suggest that the C-H bond activation step may not be the rate-determining step. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Synthetic Route of 79815-20-6
The Article related to aryl indazole alkenyl preparation diastereoselective regioselective, alkyne aryl indazole alkenylation manganese catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Synthetic Route of 79815-20-6
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles