On January 19, 1990, Tsuji, Yasushi; Kotachi, Shinji; Huh, Keun Tae; Watanabe, Yoshihisa published an article.Application of 52537-00-5 The title of the article was Ruthenium-catalyzed dehydrogenative N-heterocyclization. Indoles from 2-aminophenethyl alcohols and 2-nitrophenethyl alcohols. And the article contained the following:
Indole derivatives I (R = H, 6-Me, 5-MeO, 4-Cl, 6-Cl, 4-Br) were readily obtained from 2-aminophenethyl alcs. in the presence of 2 mol % of RuCl2(PPh3)3 under reflux in toluene. I(R = H) obtained from 2-aminophenethyl alc. quant. Other I were also obtained in 73-99% isolated yields. The 2-aminophenethyl alcs. were easily prepared by condensation between the corresponding 2-nitrotoluenes and aldehydes followed by reduction During the reaction, a stoichiometric amount of hydrogen was spontaneously evolved into the gas phase. With a heterogeneous and homogeneous binary catalyst system, indoles were afforded in one pot from 2-nitrophenethyl alcs. under a hydrogen atm. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Application of 52537-00-5
The Article related to indole, aminophenethyl alc dehydrogenation cyclization ruthenium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles