On June 13, 2013, Yang, Shyh-Ming; Kuo, Gee-Hong; Gaul, Micheal D.; Rano, Thomas A. published a patent.Recommanded Product: 52537-00-5 The title of the patent was Preparation of substituted piperidinyl-pyridazinyl derivatives as SCD1 inhibitors. And the patent contained the following:
The title compounds I [R1 = P1, P2, P3, etc.; wherein m = 0-3; R2 = halo, C1-4 alkyl, C1-4 alkoxy, etc.; R3 = Q1, Q2, Q3, etc.; wherein R4 = H, halo, C1-4 alkyl, etc.] or pharmaceutically acceptable salts thereof were prepared Compounds I are useful as Stearoyl-CoA desaturase 1 (SCD1) inhibitors for treatment of obesity, type 2 diabetes and other related metabolic disorders. For example, compound II was prepared in a multi-step synthesis and displayed IC50 of 0.12 μM against SCD1 in A431 cells. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Recommanded Product: 52537-00-5
The Article related to piperidinyl pyridazinyl derivative preparation scd1 inhibitor, obesity type 2 diabetes treatment piperidinyl pyridazinyl derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Recommanded Product: 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles