On March 7, 2013, Courtney, Stephen Martin; Prime, Michael; Mitchell, William; Brown, Christopher John; De Aguiar Pena, Paula C.; Johnson, Peter; Dominguez, Celia; Toledo-Sherman, Leticia M.; Munoz, Ignacio published a patent.Computed Properties of 52537-00-5 The title of the patent was Preparation of phenylpyrimidine derivatives and analogs for use as kynurenine-3-monooxygenase inhibitors. And the patent contained the following:
Title compounds I [L = C(O), C(O)O, C(O)NR4, NR4S(O)2, etc.; X and Y independently = N or CH, provided at least one is N; R1 = (un)substituted aryl or heteroaryl; R2 = H or alkyl; R3 = H, OH, halo, alkyl, etc.; R4 and R5 taken together with the N atom to which they are attached to form an (un)substituted heterocycloalkyl, aryl, heteroaryl, etc.; with provisions], and their pharmaceutically acceptable salts, are prepared and disclosed as kynurenine-3-monooxygenase inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated as kynurenine-3-monooxygenase inhibitors (data given). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Computed Properties of 52537-00-5
The Article related to pyrimidine derivative preparation kynurenine monooxygenase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles