Saczewski, Franciszek published the artcile1-[(Imidazolin-2-yl)amino]indoline and 1-[(imidazolin-2-yl)amino]1,2,3,4-tetrahydroquinoline derivatives: new insights into their circulatory activities, Category: indole-building-block, the main research area is imidazolinylamino indoline hydrochloride preparation mol modeling imidazoline adrenoceptor antihypertensive; quinoline imidazolinylamino hydrochloride preparation mol modeling imidazoline adrenoceptor antihypertensive.
N-[(Imidazolinyl)amino]indoline-hydrochlorides I·HCl [R = H, 2-CH3, 7-CH3, 4-Cl] and N-[(imidazolinyl)amino]tetrahydroquinoline-hydrochlorides II·HCl [R = H, 8-CH3] were synthesized and tested in vitro for their affinities to α1 and α2-adrenoceptors as well as imidazoline I1 and I2 receptors. The compounds most potent at either α1 or α2-adrenoceptors were administered i.v. to normotensive Wistar rats to determine their effects on mean arterial blood pressure and heart rate. Upon i.v. administration at dose of 0.1 mg/kg to normotensive male Wistar rats, the initial transient pressor effect was followed by long-lasting hypotension and bradycardia. The results revealed that the synthesized compounds I and II were found to possess circulatory profile characteristic of the centrally acting clonidine-like hypotensive imidazolines.
Acta Poloniae Pharmaceutica published new progress about Adrenoceptor antagonists. 41910-64-9 belongs to class indole-building-block, name is 4-Chloroindoline, and the molecular formula is C8H8ClN, Category: indole-building-block.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles