Ito, Yoshihiko published the artcileIndole syntheses with o-tolyl isocyanide. 3-Acylindoles and 2-substituted indoles, Safety of 2-(tert-Butyl)-5-chloro-1H-indole, the main research area is indole acyl; tolyl isocyanide acylation; cyclization acylmethylphenyl isocyanide.
o-(Lithiomethyl)phenyl isocyanide, generated from o-tolyl isocyanide and (Me2CH)2NLi in diglyme, reacts with allyl esters to produce o-(acylmethyl)phenyl isocyanides. Similarly, acylation of 4-chloro-2-methylphenyl isocyanide, 2,4-dimethylphenyl isocyanide, and 2,6-dimethylphenyl isocyanide produces the corresponding o-(acylmethyl)phenyl isocyanides in moderate yields. o-(Acylmethyl)phenyl isocyanides are heated with Cu2O catalyst in benzene to give 3-acylindole. o-(Acylmethyl)phenyl isocyanides are hydrolyzed to afford 2-alkyl(or 2-aryl)indoles.
Journal of Organic Chemistry published new progress about Cyclization. 69622-40-8 belongs to class indole-building-block, name is 2-(tert-Butyl)-5-chloro-1H-indole, and the molecular formula is C12H14ClN, Safety of 2-(tert-Butyl)-5-chloro-1H-indole.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles