Mosser, Eric A. published the artcileIdentification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen, SDS of cas: 330161-87-0, the publication is Scientific Reports (2019), 9(1), 1-14, database is CAplus and MEDLINE.
The circadian clock ensures that behavioral and physiol. processes occur at appropriate times during the 24-h day/night cycle, and is regulated at both the cellular and organismal levels. To identify pathways acting on intact animals, we performed a small mol. screen using a luminescent reporter of mol. circadian rhythms in zebrafish larvae. We identified both known and novel pathways that affect circadian period, amplitude and phase. Several drugs identified in the screen did not affect circadian rhythms in cultured cells derived from luminescent reporter embryos or in established zebrafish and mammalian cell lines, suggesting they act via mechanisms absent in cell culture. Strikingly, using drugs that promote or inhibit inflammation, as well as a mutant that lacks microglia, we found that inflammatory state affects circadian amplitude. These results demonstrate a benefit of performing drug screens using intact animals and provide novel targets for treating circadian rhythm disorders.
Scientific Reports published new progress about 330161-87-0. 330161-87-0 belongs to indole-building-block, auxiliary class Protein Tyrosine Kinase/RTK,Src, name is SU6656, and the molecular formula is C19H21N3O3S, SDS of cas: 330161-87-0.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles