El-Gendy, Adel A. published the artcileSynthesis and antihypertensive activity of certain Mannich bases of 2-ethoxycarbonylindoles and 5H-pyridazino[4,5-b]indoles, SDS of cas: 100123-25-9, the publication is Archives of Pharmacal Research (2001), 24(1), 21-26, database is CAplus and MEDLINE.
The synthesis of 3-(aminomethyl)-1H-indole-2-carboxylic acid Et ester derivatives and of 3-(aminomethyl)-3,5-dihydro-4H-pyridazino[4,5-b]indol-4-one derivatives was reported. Fourteen of the synthesized Mannich bases were screened as antihypertensive agents in normotensive anesthetized rats. The effect of 3-[(diethylamino)methyl]-1H-indole-2-carboxylic acid Et ester hydrochloride in normotensive anesthetized dogs was also studied.
Archives of Pharmacal Research published new progress about 100123-25-9. 100123-25-9 belongs to indole-building-block, auxiliary class Indole,Bromide,Ester,Aldehyde, name is Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate, and the molecular formula is C12H10BrNO3, SDS of cas: 100123-25-9.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles