Simpson, Levi S. published the artcileA cleavable scaffold strategy for the synthesis of one-bead one-compound cyclic peptoid libraries that can be sequenced by tandem mass spectrometry, SDS of cas: 167015-84-1, the publication is Tetrahedron Letters (2012), 53(18), 2341-2344, database is CAplus and MEDLINE.
Many macrocyclic depsipeptides or related compounds have interesting medicinal properties and often display more favorable pharmacokinetic properties than linear analogs. Therefore, there is considerable interest in the development of large combinatorial libraries of macrocyclic peptidomimetic compounds However, such mols. cannot be easily sequenced by tandem mass spectrometry, making it difficult to identify hits isolated from library screens using one bead one compound libraries. Here we report a strategy to solve this problem by placing a methionine in both the linker connecting the cyclic mol. to the bead as well as within the cycle itself. Treatment with CNBr both linearizes the mol. at a specific position and releases the mol. from the bead, making its characterization by tandem MALDI mass spectrometry straightforward.
Tetrahedron Letters published new progress about 167015-84-1. 167015-84-1 belongs to indole-building-block, auxiliary class Indols, name is tert-Butyl 3-(2-aminoethyl)-1H-indole-1-carboxylate, and the molecular formula is C23H23ClN2O4, SDS of cas: 167015-84-1.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles