Chauhan, Jyoti published the artcileBlue LED Mediated Intramolecular C-H Functionalization and Cyclopropanation of Tryptamines: Synthesis of Azepino[4, 5-b]indoles and Natural Product Inspired Polycyclic Indoles, Synthetic Route of 167015-84-1, the publication is Organic Letters (2020), 22(11), 4537-4541, database is CAplus and MEDLINE.
A novel blue LED mediated intramol. C-H functionalization of tryptamine derivatives to generate azepino[4, 5-b]indoles, e. g., I, in moderate to good yields is reported. By altering the substitution at the tryptamine nitrogen, intramol. cyclopropanation is achieved in high yields under the same reactions condition to provide natural product inspired polycyclic indoles, e. g., II, which are further transformed to spiropiperidino indoles, e. g., III, in decent yields. The mechanism of formation of the compounds was investigated through DFT studies.
Organic Letters published new progress about 167015-84-1. 167015-84-1 belongs to indole-building-block, auxiliary class Indols, name is tert-Butyl 3-(2-aminoethyl)-1H-indole-1-carboxylate, and the molecular formula is C15H20N2O2, Synthetic Route of 167015-84-1.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles