Mueting, Dieter published the artcileDisturbances in protein metabolism in renal insufficiency, Recommanded Product: Potassium 1H-indol-3-yl sulfate, the publication is Protides of the Biological Fluids (1962), 148-54, database is CAplus.
Studies were conducted in 129 patients with renal insufficiency resulting from glomerulonephritis and pyelonephritis. Total serum protein and albumin were decreased and α1-, α2– and γ-globulins were increased to an extent proportional to the degree of uremia. Tyrosine and tryptophan were elevated in serum, as well as their phenolic and indolyl catabolites. Increased concentrations of the latter were due not only to decreased urinary excretion but also to decrease oxidative processes. Impairment of oxidation reactions in uremia was also reflected by elevation of sulfate esters. Detoxication processes involving glucuronic acid, as well as sulfate conjugation, are impaired which further aggravates the toxic conditions produced by uremia. The most sensitive criteria of incipient renal insufficiency appeared to be the retention of creatinine and indican, obtained by analyses of their serum and urinary levels.
Protides of the Biological Fluids published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Recommanded Product: Potassium 1H-indol-3-yl sulfate.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles