Bandi, Madhu et al. published their research in Journal of Heterocyclic Chemistry in 2017 | CAS: 827-01-0

One-Pot, Step-Wise, Alternative Syntheses of Quinoline-Substituted Bis(Indolyl)Methanes Using a Green Approach was written by Bandi, Madhu;Ch., Venkata Ramana Reddy. And the article was included in Journal of Heterocyclic Chemistry in 2017.Application In Synthesis of 5-Chloroindole-3-carboxaldehyde This article mentions the following:

A green and highly efficient protocol for one-pot, step-wise, alternative syntheses of quinoline-substituted bis(indolyl)methanes has been described by the condensation of N-Me or N-Et quinolone-4-one-3-carbaldehydes with indoles in water containing a catalytic amount of L-proline to afford the title compounds, e.g., I, in high yields and in shorter reaction times. This reaction involves easy workup without using column chromatog. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Application In Synthesis of 5-Chloroindole-3-carboxaldehyde).

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Application In Synthesis of 5-Chloroindole-3-carboxaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles