Indole-3-carbaldehyde semicarbazone derivatives: Synthesis, characterization, and antibacterial activities was written by Carrasco, Fernando;Hernandez, Wilfredo;Chupayo, Oscar;Alvarez, Celedonio M.;Oramas-Royo, Sandra;Spodine, Evgenia;Tamariz-Angeles, Carmen;Olivera-Gonzales, Percy;Davalos, Juan Z.. And the article was included in Journal of Chemistry in 2020.Category: indole-building-block This article mentions the following:
Four indole-3-carbaldehyde semicarbazone derivatives, I (R = H, R1 = Br, Cl, OMe; R = NO2, R1 = H) were synthesized and characterized by ESI-MS and spectroscopic (FT-IR, 1H NMR, and 13C NMR) techniques. The two-dimensional NMR (in acetone-d6) spectral data revealed that the mols. I (R = H, R1 = Br, Cl) (II) in solution are in the cis E isomeric form. This evidence is supported by DFT calculations at the B3LYP/6-311++G(d,p) level of theory where it was shown that the corresponding most stable conformers of the synthesized compounds have a cis E geometrical configuration, in both the gas and liquid (acetone and DMSO) phases. The in vitro antibacterial activity of I was determined against Gram-pos. (Staphylococcus aureus and Bacillus subtilis) and Gram-neg. (Pseudomonas aeruginosa and Escherichia coli) bacteria. Among all the tested semicarbazones, II exhibited similar inhibitory activities against Staphylococcus aureus (MIC = 100 and 150μg/mL, resp.) and Bacillus subtilis (MIC = 100 and 150μg/mL, resp.). On the other hand, I (R = H, R1 = OMe; R = NO2, R1 = H) were relatively less active against the tested bacterial strains compared with II and tetracycline. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Category: indole-building-block).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Category: indole-building-block
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles