Synthesis and Biological Evaluation of New Isatin-Based QACs with High Antimicrobial Potency was written by Bogdanov, Andrei V.;Zaripova, Ilyuza F.;Voloshina, Alexandra D.;Sapunova, Anastasia S.;Kulik, Natalia V.;Bukharov, Sergey V.;Voronina, Julia K.;Vandyukov, Alexander E.;Mironov, Vladimir F.. And the article was included in ChemistrySelect in 2019.SDS of cas: 150560-58-0 This article mentions the following:
A simple and easy condensation reaction of aryl- or N-substituted isatins with Girard’s reagents P and T was described for the synthesis of water-soluble isatin-3-acylhydrazone-based quaternary ammonium compounds (QACs) I [R = H, F, Br; R1 = H, Me, OMe, etc.; R2 = H, Br; R3 = H, Et, NO2, etc.; R4 = H, (3,5-ditert-butyl-4-hydroxy-phenyl)methyl; R5 = trimethylammonio, pyridinium-1-yl] with high yields. Synthesized compounds were evaluated for their antibacterial and antifungal activities against Gram-pos. bacteria (S. aureus 209p and B. cereus 8035) and yeast-like fungus C. albicans 855-653. Among them three compounds I [R = H; R1 = Me, Et, F, Br; R2 = H; R3 = H; R4 = (3,5-ditert-butyl-4-hydroxy-phenyl)methyl; R5 = pyridinium-1-yl] exhibited very promising antibacterial activities. The influence of the substituent’s nature as in the aromatic fragment as at position 1 on the activity was established. The structures of all novel compounds I were fully characterized using IR and NMR spectroscopies as well as XRD anal. In the experiment, the researchers used many compounds, for example, 5-Isopropylindoline-2,3-dione (cas: 150560-58-0SDS of cas: 150560-58-0).
5-Isopropylindoline-2,3-dione (cas: 150560-58-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). SDS of cas: 150560-58-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles