Unexpected synthesis of azepino[4,3,2-cd]indoles from 4-aminoindoles was written by Halaiev, Olexandr;Garazd, Myroslav;Gzella, Andrzej;Lesyk, Roman. And the article was included in Tetrahedron Letters in 2017.Quality Control of 1-Methyl-1H-indol-4-amine This article mentions the following:
Synthesis of azepinoindoles I [R = Me, CH(Me)2, CH2C6H5, etc.] instead of quinolines from the regioselective Skraup-Doebner-Von Miller reaction of 4-aminoindoles and acetone in the presence of hydrochloric acid as a catalyst was developed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indol-4-amine (cas: 85696-95-3Quality Control of 1-Methyl-1H-indol-4-amine).
1-Methyl-1H-indol-4-amine (cas: 85696-95-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Quality Control of 1-Methyl-1H-indol-4-amine
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles