Synthesis of substituted carbazoles and β-carbolines by cyclization of diketoindole derivatives was written by Duval, Eric;Cuny, Gregory D.. And the article was included in Tetrahedron Letters in 2004.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid This article mentions the following:
A new route to substituted β-carbolines and carbazoles is described. Diketoindole intermediates, prepared by Friedel-Crafts acylations of 3-substituted indoles, were converted to 3-hydroxycarbazoles and β-carbolines in good yields, 51-96% and 82-97%, resp. This method also allows for the formation of 4-substituted β-carbolines. The application of this methodol. to the synthesis of the natural products hyellazole and 6-chlorohyellazole is also described. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid).
2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles