1-Ethylthio-2R-isoindoles. An example of nonsynchronous addition in the Diels-Alder reaction was written by Kovtunenko, V. A.;Dobrenko, T. T.;Voitenko, Z. V.;Tyltin, A. K.;Babichev, F. S.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1984.Product Details of 5388-42-1 This article mentions the following:
Treating isoindolinones I (R = Me, Ph, p-MeC6H4, p-MeOC6H4, X = O) with P2S5 in refluxing pyridine gave 53-70% I (X = S) which were converted to 50-80% indolium salts II by treatment with Meerwein’s reagent. Treating II with dry base gave 45-50% III which underwent an non-synchronous Diels-Alder addition with N-phenyl- or N-(p-methoxyphenyl)maleimides to give 90% adducts IV (R1 = p-MeOC6H4 or Ph) or V. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Product Details of 5388-42-1).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Product Details of 5388-42-1
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles