A facile synthesis of pyrrolo[2,3-j]phenanthridines via the cascade reaction of indoleanilines and aldehydes was written by Huang, Wen-Jun;Chen, Zhi-Peng;Liu, Li-Xia;Zhou, Yong-Gui;Wu, Bo;Jiang, Guo-Fang. And the article was included in Journal of Heterocyclic Chemistry in 2022.Category: indole-building-block This article mentions the following:
A facile method for the synthesis of pyrrolo[2,3-j]phenanthridines from indoleanilines and aldehydes in the presence of Broensted acid catalyst and benzoquinone oxidant were established. This approach featured excellent yields, high efficiency and a wide range of substrate scope. Mechanism studies exhibited that this reaction was a cascade process including acid-catalyzed condensation of indoleanilines with aldehydes, cyclization and oxidative aromatization. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Category: indole-building-block).
5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles