Application of the mild-condition phthalimidine synthesis with use of 1,2,3-1H-benzotriazole and 2-mercaptoethanol as dual synthetic auxiliaries. Effective synthesis of phthalimidines possessing a variety of substituents at 2-position was written by Takahashi, Ichiro;Kawakami, Teruki;Hirano, Etsushi;Kimino, Mako;Kamimura, Shigeki;Miwa, Takayuki;Tamura, Takanori;Tazaki, Ryo;Kitajima, Hidehiko;Hatanaka, Minoru;Isa, Kimio;Hosoi, Shinzo. And the article was included in Heterocycles in 2016.Reference of 5388-42-1 This article mentions the following:
Synthesis of 2-substituted phthalimidines (2,3-dihydroisoindol-1-one) I [R = t-Bu, C6H5, c-C6H11, etc.] were described via Mannich type condensation reaction between o-phthalaldehyde with a variety of primary amines in the presence of excess 2-mercaptoethanol and 1,2,3-1H-benzotriazole as dual synthetic auxiliaries. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Reference of 5388-42-1).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Reference of 5388-42-1
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles