Synthesis and antimicrobial activity of some derivatives of 5-substituted indole dihydropyrimidines was written by Heda, L. C.;Sharma, Rashmi;Pareek, C.;Chaudhari, P. B.. And the article was included in E-Journal of Chemistry in 2009.Category: indole-building-block This article mentions the following:
Haloindole substituted dihydropyrimidines I (R = H, Br, Cl, I; X = O or S) have been prepared via Bignelli reaction of haloformylindoles with urea (or thiourea) and ethylacetoacetate. I were evaluated for their antibacterial and antifungal activity with the min. inhibitory concentration (MIC) determined by micro dilution technique in Mueller-Hinton broth. The MICs were recorded after 24 h of incubation at 37闂? These results are promising, showing these compounds are biol. active. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Category: indole-building-block).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles