Synthesis of substituted 1,3-dihydroindolin-2-ones was written by Zhou, Feng;Zheng, Canhui;Zhu, Ju;Liu, Jia;Zhou, Youjun. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2013.Computed Properties of C8H6BrNO This article mentions the following:
The substituted 1,3-dihydroindolin-2-one compounds 1a-1k, the intermediates of tyrosine kinase inhibitors such as sunitinib, were synthesized from substituted anilines by acylation and cyclization to give substituted isatin derivatives followed by reduction with triethylsilane/trifluoroacetic acid. In the experiment, the researchers used many compounds, for example, 7-Bromooxindole (cas: 320734-35-8Computed Properties of C8H6BrNO).
7-Bromooxindole (cas: 320734-35-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Computed Properties of C8H6BrNO
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles