Preparation of Functionalized Arylmagnesium Reagents Bearing an o-Chloromethyl Group was written by Delacroix, Thomas;Berillon, Laurent;Cahiez, Gerard;Knochel, Paul. And the article was included in Journal of Organic Chemistry in 2000.Formula: C14H11NO This article mentions the following:
The selective iodine-magnesium exchange of 2-chloromethyl-1-iodobenzenes such as 3,2-I(ClCH2)C6H3R (R = H CO2Me) are reported. The resulting organomagnesium reagents 3,2-(BrMg)(ClCH2)C6H3R (R = same as above) are synthetic equivalent of a zwitterionic synthon and prove to be well suited for participation in cyclization reactions. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Formula: C14H11NO).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Formula: C14H11NO
Referemce:
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles