N-(Hydroxyalkyl) derivatives of tris(1H-indol-3-yl)methylium salts as promising antibacterial agents: synthesis and biological evaluation was written by Lavrenov, Sergey N.;Isakova, Elena B.;Panov, Alexey A.;Simonov, Alexander Y.;Tatarskiy, Viktor V.;Trenin, Alexey S.. And the article was included in Pharmaceuticals in 2020.Reference of 6639-06-1 This article mentions the following:
The main objective of the study was to prepare and elucidate the effect of substitutions in tris(1H-indol-3-yl)methylium derivatives I [n = 1,2,3,4,5] on their antibacterial activity and toxicity to human cells. Antibacterial activity of compounds I was performed in vitro on 12 bacterial strains, including drug resistant strains, that were clin. isolates or collection strains. The cytotoxic effect of the compounds was determined using an test with HPF-hTERT (human postnatal fibroblasts, immortalized with hTERT) cells. The min. inhibitory concentration (MIC) of the most active compound I [n = 5] on Gram-pos. bacteria, including MRSA, was 0.5濠电偞鎸鹃幐?mL. Compounds I [n = 4,5] also revealed high activity against Staphylococcus epidermidis (1.0 and 0.5濠电偞鎸鹃幐?mL, resp.) and moderate activity against Gram-neg. bacteria Escherichia coli (8濠电偞鎸鹃幐?mL) and Klebsiella pneumonia (2 and 8濠电偞鎸鹃幐?mL, resp.). However, they had no activity against Salmonella cholerasuis and Pseudomonas aeruginosa. The most active compounds I [n = 4,5] revealed higher antibacterial activity on MRSA than the reference drug levofloxacin, and their ratio between antibacterial and cytotoxic activity exceeded 10 times. In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1Reference of 6639-06-1).
3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Reference of 6639-06-1
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles