Solvent-free multi-component synthesis of unsymmetrical bis(indolyl)alkanes with Lewis acid-surfactant-SiO2 as nanocatalyst was written by Wu, Zhiqiang;Wang, Gang;Li, Zhenliang;Feng, Enke;Liang, Yanping;Zhan, Haijuan;Liu, Wanyi. And the article was included in Synthetic Communications in 2021.Related Products of 4769-96-4 This article mentions the following:
Herein, the multicomponent synthesis of the bis(indolyl)methane derivatives in a ball mill were reported. The reaction was carried out under solvent-free conditions using only the Lewis acid-surfactant-SiO2 composite nanocatalyst (LASSC) prepared in situ. The unsym. bis(indolyl) methane derivatives containing nitro or fluorine substitution with a yield of 72%-92% were obtained in a short reaction time. Under the action of the verified combined catalyst of AlCl3闁?H2O + SDS + SiO2, the method of preparing unsym. bis(indolyl)methane by mech. grinding without solvent was obvious advantages. Finally, the catalysis system was used eight times without a significant decrease in activity were inspected. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Related Products of 4769-96-4).
6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Related Products of 4769-96-4
Referemce:
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles