Remote Control of Axial Chirality: Synthesis of Spirooxindole-Urazoles via Desymmetrization of ATAD was written by Zhang, Lin-Lin;Zhang, Ji-Wei;Xiang, Shao-Hua;Guo, Zhen;Tan, Bin. And the article was included in Organic Letters in 2018.Category: indole-building-block This article mentions the following:
In the presence of a nonracemic bisthiourea, 3-vinylindoles and N-Boc alkylideneoxindoles underwent diastereoselective and enantioselective tandem Diels-Alder and ene reactions and desymmetrization with triazolinediones in hexane to yield spirooxindolecarbazolylurazoles such as I containing axial chirality in 49-84% yields, 3:1-10:1 dr at the atropisomeric axes, and in 93->99% ee. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Category: indole-building-block).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles