Hexafluoroisopropyl Sulfamate: A Useful Reagent for the Synthesis of Sulfamates and Sulfamides was written by Sguazzin, Matthew A.;Johnson, Jarrod W.;Magolan, Jakob. And the article was included in Organic Letters in 2021.Application In Synthesis of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole This article mentions the following:
Sulfamates and sulfamides were most often synthesized from alcs. and amines with sulfamoyl chloride, which was an unstable reagent. Hexafluoroisopropyl sulfamate (HFIPS) as a bench-stable solid that reacts readily with a wide variety of alcs., amines, phenols, and anilines under mild reaction conditions was identified. The sole byproduct of the reaction was hexafluoroisopropanol (HFIP) and reaction products was often isolated in high purity after an aqueous workup (optional) and removal of solvents by evaporation In the experiment, the researchers used many compounds, for example, 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole (cas: 16502-01-5Application In Synthesis of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole).
2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole (cas: 16502-01-5) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Application In Synthesis of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles