Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5 was written by Moorhouse, Adam D.;Spiteri, Christian;Sharma, Pallavi;Zloh, Mire;Moses, John E.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2011.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate This article mentions the following:
HLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate).
Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles