Organocatalytic Enantioselective Construction of Axially Chiral Tetrasubstituted Allenes via 1,6-Addition of Alkynyl Indole Imine Methides with 2-Substituted Indoles was written by Wu, Yu;Yue, Zhibin;Qian, Chenxiao;Chen, Xuling;Li, Fushuai;Li, Pengfei;Li, Wenjun. And the article was included in Asian Journal of Organic Chemistry in 2022.Name: 3-Methyl-1H-indole This article mentions the following:
An organocatalytic construction of axially chiral tetrasubstituted allenes I [R1 = H, 5-F, 6-OMe, etc.; R2 = H, F, Cl, Br; R3 = Me, t-Bu, Ph, etc.; R4 = Et, i-Pr, t-Bu, Bn; Ar1 = Ph, 4-FC6H4, 3-FC6H4, 3-MeC6H4] featuring indole skeletons was established. With the aid of chiral phosphoric acid, alkynyl indole imine methides were formed in situ from α-(3-indolyl) propargylic alcs., followed by the asym. 1,6-conjugate addition with 2-substituted indoles, furnishing axially chiral indole-containing tetrasubstituted allenes in generally high yields and enantioselectivities. In the experiment, the researchers used many compounds, for example, 3-Methyl-1H-indole (cas: 83-34-1Name: 3-Methyl-1H-indole).
3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Name: 3-Methyl-1H-indole
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles