Totoki, Shintaro et al. published their research in Rikogaku Kenkyusho Hokoku, Waseda Daigaku in 1987 | CAS: 3130-75-4

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 3130-75-4

Reaction of phthalimidoalkyl radicals with 蟺-deficient olefins was written by Totoki, Shintaro;Tada, Masaru. And the article was included in Rikogaku Kenkyusho Hokoku, Waseda Daigaku in 1987.HPLC of Formula: 3130-75-4 This article mentions the following:

蠅-Phthalimidoalkanoic acids (I, R = H, Me; n = 0-2) give 蠅-phthalimidoalkyl radicals on Ag ion-mediated oxidation with dioxopersulfate. The radicals thus formed add to electron-deficient olefins such as crotononitrile and Me crotonate to afford 蠅-phthalimidoalkanenitrile (II, R1 = CN) and 蠅-phthalimidoalkanoate (II, R1 = CO2Me). In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4HPLC of Formula: 3130-75-4).

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 3130-75-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles