A New Approach to Isoindolinones: Rhodium(III)-Catalyzed [3+2] Annulation Reactions of N-Methoxybenzamides with Bis(tosylamido)methane was written by Fang, Zhang;Shu, Sai;Zhou, Guanyu;Deng, Zefeng;Huang, Pengcheng;Li, Bao;Zhao, Yingsheng. And the article was included in European Journal of Organic Chemistry in 2022.Reference of 480-91-1 This article mentions the following:
A new approach to the synthesis of isoindolinones I (R = H, Me, OMe, etc.; R1 = Me, OPh, Cl, etc.; R2 = Cl, Me, (cyclopropylmethyl)oxidanyl, etc.; R3 = H, Cl; R4 = H, 2-Me, 4-Br, etc.) via direct coupling of N-methoxybenzamides 2R-3R1-4R2-5R3C6HC(O)NHOMe and bis(tosylamido)methane (R4NH)2CH2 with rhodium(III) as catalyst has been developed. The reaction is performed under mild conditions without oxidant, and is compatible with various functional groups. Compared with the previously reported methods for constructing isoindolinone skeletons, this method involves a novel [3+2] cyclization, and affords a wide variety of isoindolinones I in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, Isoindolin-1-one (cas: 480-91-1Reference of 480-91-1).
Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 480-91-1
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles