Luan, Xinjun et al. published their research in Organic Letters in 2010 | CAS: 1912-48-7

1-Methyl-3-indoleacetic acid (cas: 1912-48-7) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Application In Synthesis of 1-Methyl-3-indoleacetic acid

Highly Chemo- and Enantioselective Synthesis of 3-Allyl-3-aryl Oxindoles via the Direct Palladium-Catalyzed 伪-Arylation of Amides was written by Luan, Xinjun;Wu, Linglin;Drinkel, Emma;Mariz, Ronaldo;Gatti, Michele;Dorta, Reto. And the article was included in Organic Letters in 2010.Application In Synthesis of 1-Methyl-3-indoleacetic acid This article mentions the following:

Nonracemic cinnamyl imidazolidinylenepalladium complexes such as I (R = Et2CH) are prepared as catalysts for the chemoselective and enantioselective arylation of N-(2-bromophenyl) allyl-substituted acetamides such as II (R1 = Ph, 1-naphthyl, 2-naphthyl, 2-MeC6H4, 2-FC6H4, 2-MeOC6H4, 4-MeC6H4, 4-FC6H4, 4-F3CC6H4, 4-PhC6H4, 3-MeC6H4, 3-FC6H4, 3-MeOC6H4, 3,5-Me2C6H3, 1-Me-3-indolyl, Me; R2 = H, Me; R3 = H, MeO) to give nonracemic (aryl)(allyl)oxindoles such as III (R1 = Ph, 1-naphthyl, 2-naphthyl, 2-MeC6H4, 2-FC6H4, 2-MeOC6H4, 4-MeC6H4, 4-FC6H4, 4-F3CC6H4, 4-PhC6H4, 3-MeC6H4, 3-FC6H4, 3-MeOC6H4, 3,5-Me2C6H3, 1-Me-3-indolyl, Me; R2 = H, Me; R3 = H, MeO) in 40-98% yields and in 4-91% ee (with all but three of the 21 examples in 69-91% ee) with none of the isomeric benzazepinone products formed in most cases. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-indoleacetic acid (cas: 1912-48-7Application In Synthesis of 1-Methyl-3-indoleacetic acid).

1-Methyl-3-indoleacetic acid (cas: 1912-48-7) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Application In Synthesis of 1-Methyl-3-indoleacetic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles