Organic superbase t-Bu-P4-catalyzed demethylations of methoxyarenes was written by Shigeno, Masanori;Hayashi, Kazutoshi;Korenaga, Toshinobu;Nozawa-Kumada, Kanako;Kondo, Yoshinori. And the article was included in Organic Chemistry Frontiers in 2022.Recommanded Product: 1-Methyl-1H-indol-5-ol This article mentions the following:
The organic superbase t-Bu-P4 catalyzes the demethylation reactions of methoxyarenes ROMe [R = 4-cyanophenyl, 1-oxo-2,3-dihydro-1H-inden-5-yl, 1-benzothiophen-5-yl, etc.] in the presence of alkanethiol and hexamethyldisilazane was reported. The system can efficiently convert a variety of substrates, including electron-deficient, -neutral, and -rich substrates and heteroaromatic substrates, and displays excellent functional group tolerance. Computational studies show that the high reactivity achieved by t-Bu-P4 is due to the formation of the nucleophilic naked thiolate species. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indol-5-ol (cas: 13523-92-7Recommanded Product: 1-Methyl-1H-indol-5-ol).
1-Methyl-1H-indol-5-ol (cas: 13523-92-7) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Recommanded Product: 1-Methyl-1H-indol-5-ol
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles