尾-Carboline-3-carboxylate-tert-butyl ester: a selective BZ1 benzodiazepine receptor antagonist was written by Shannon, H. E.;Guzman, F.;Cook, J. M.. And the article was included in Life Sciences in 1984.Formula: C16H16N2O2 This article mentions the following:
The effectiveness of 尾-carboline-3-carboxylate-tert-Bu聽ester (尾CCtB) [93835-05-3] in antagonizing the anticonvulsant, ataxic, and antipunishment effects of diazepam were evaluated. The mice, 尾CCtB at doses of 3 and 10 mg/kg produced a dose-related antagonism of the anticonvulsant effects of diazepam against pentylenetetrazole (80 mg/kg). A dose of 30 mg/kg of BCCtB did not produce a further shift in the diazepam dose-effect curve, apparently because 尾CCtB failed to block the muscle-relaxant effects of diazepam. Further, 尾CCtB (30 mg/kg) failed to antagonize the ataxic effects of diazepam in an inverted screen test. Rats responded under a multiple schedule where in one component every twentieth response (FR20) resulted in water presentation (unpunished component) and in another component every twentieth response (FR20) resulted in both shock and water presentation (punished component). Diazepam orally (0.1 to 10 mg/kg) first increased and then decreased rates in the punished component but only decreased rates in the unpunished component. 尾CCtB had no effect on response rates when administered alone, but antagonized the rate-increasing effects of diazepam in the punished component. 尾CCtB did not alter the rate-decreasing effects of diazepam in either component. Thus, 尾CCtB selectively antagonized the effects of diazepam on punished behavior as well as the anticonvulsant effects of diazepam, but 尾CCtB failed to antagonize the rate-decreasing and ataxic effects of diazepam. These results are consistent with the interpretation that 尾CCtB is a selective BZ1 benzodiazepine receptor antagonist. In the experiment, the researchers used many compounds, for example, tert-Butyl 9H-pyrido[3,4-b]indole-3-carboxylate (cas: 93835-05-3Formula: C16H16N2O2).
tert-Butyl 9H-pyrido[3,4-b]indole-3-carboxylate (cas: 93835-05-3) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Formula: C16H16N2O2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles