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A method for synthesis of indole derivatives (by machine translation)
The invention relates to a kind of the formula shown in (III) method for synthesis of indole derivatives, the method comprises in a solvent under an inert gas atmosphere and, in catalyst, a nitrogen-containing ligand, in the presence of acid promoter and KF, represented by the formula (I) compound with the following formula (II) compound generating reaction, after-treatment after reaction, so as to obtain the compound of said formula (III), wherein R 1 is selected from H or halogen; R 2 selected from H, C 1 ? C 6 alkyl, C 1 ? C 6 alkoxy or halogen. The stated method, through suitable substrate, catalyst, a nitrogen-containing ligand, acidic promoter and KF and the overall solvent selection with the cooperative, thereby expanding the range of the substrate, and the yield is indole derivatives can be good, thus the in the field of organic chemical synthesis has good application prospect and research value, for the synthesis of such compounds to provide a completely new method. (by machine translation)
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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles